Prevention Of Oxidative Cell Injury With Antioxidants And Poly(Adp Ribose) Polymerase Inhibitors

Cardiovascular diseases and especially ischemic heart disease are the major cause of death in adults and among elderly patients in developed countries. Reactive oxygen species (ROS) play a key role in the pathogenesis of this disease. Although cells have developed defense systems against oxidative injury, there are certain circumstances when the oxidative threats exceed the capacity of the defense system, causing an oxidative stress to the cell. Lipid peroxidation, protein oxidation, DNA damages, activation of poly(ADP-ribose) polymerase enzyme, NAD catabolism and decrease of the high-energy phosphate concentration in myocardial cells and consequently loss of contractile function of myocardium are some of the most important consequences of the oxidative stress. This book discusses not only some of the pathological pathways induced by ROS, but also some of the possibilities of the antioxidant defense, such as novel antiarrhythmic-scavenger molecules and poly(ADP-ribose) polymerase inhib

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